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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Methotrexate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Methotrexate and M1, respectively.
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The effects of Methotrexate are similar to those of narcotic analgesics. Although Methotrexate is not classified as a narcotic, it may become habit-forming,
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Methotrexate may not work as well and may require higher doses to obtain the same effect as when originally taken.
Check with your health care provider before you start, stop, or change the dose of any medicine.Use Methotrexate as directed by your doctor.
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It is slightly soluble in water and freely soluble in alcohol,
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For Methotrexate, the following should be considered:The suitability of Methotrexate.

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Intramuscular (i.m.) Methotrexate increases gastric pH during anaesthesia similar to famotidine.
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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The analgesic activity of Methotrexate is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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A single i.m. dose of Methotrexate is useful pre-treatment to minimize the risk of acid aspiration during operation,
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Methotrexate has been shown to cause harm to the fetus.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Methotrexate has been shown to cause harm to the fetus.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Methotrexate and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Methotrexate and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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