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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Aciphex and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Aciphex may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aciphex while you are pregnant.
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Talk with your doctor if Aciphex stops working well. Do not take more than prescribed.Some people who use Aciphex for a long time without a break may develop a physical need to continue taking it.
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Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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The 6-hour TOTPAR scores for the Aciphex groups and ASA/,
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The binding of Aciphex to human plasma proteins is approximately 20%,
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Aciphex is well absorbed orally with an absolute bioavailability of 75%. Aciphex has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Aciphex is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
The effects of Aciphex are similar to those of narcotic analgesics. Although Aciphex is not classified as a narcotic, it may become habit-forming,
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There were no other significant respiratory diffences.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Aciphex is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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